Synthetic antiprotozoal thiazolide drug induced apoptosis in colorectal cancer cells: implications of IL-6/JAK2/STAT3 and p53/caspases-dependent signaling …
MA Tantawy, NA El-Sherbeeny, N Helmi… - Molecular and cellular …, 2020 - Springer
Colorectal cancer (CRC) is a global pressing healthcare priority. Dysregulation of the
IL6/JAK2/STAT3 and p53/caspase downstreaming pathways are significantly involved in the
progression of CRC, and mainly affecting apoptosis. Discovery of new anti-cancer agents is
laborious, time consuming, and costly with obvious socioeconomic burden. In the present
study, we are proposing new molecular insights on the anti-proliferative and apoptotic
therapeutic effects of nitazoxanide (NTZ) on CRC. NTZ is FDA-approved thiazolide …
IL6/JAK2/STAT3 and p53/caspase downstreaming pathways are significantly involved in the
progression of CRC, and mainly affecting apoptosis. Discovery of new anti-cancer agents is
laborious, time consuming, and costly with obvious socioeconomic burden. In the present
study, we are proposing new molecular insights on the anti-proliferative and apoptotic
therapeutic effects of nitazoxanide (NTZ) on CRC. NTZ is FDA-approved thiazolide …
[PDF][PDF] Synthetic antiprotozoal thiazolide drug induced apoptosis in colorectal cancer cells: implications of IL-6/JAK2/STAT3 and p53/caspases-dependent signaling …
SM Elaidy - researchgate.net
Colorectal cancer (CRC) is a global pressing healthcare priority. Dysregulation of the
IL6/JAK2/STAT3 and p53/caspase downstreaming pathways are significantly involved in the
progression of CRC, and mainly affecting apoptosis. Discovery of new anti-cancer agents is
laborious, time consuming, and costly with obvious socioeconomic burden. In the present
study, we are proposing new molecular insights on the anti-proliferative and apoptotic
therapeutic effects of nitazoxanide (NTZ) on CRC. NTZ is FDA-approved thiazolide …
IL6/JAK2/STAT3 and p53/caspase downstreaming pathways are significantly involved in the
progression of CRC, and mainly affecting apoptosis. Discovery of new anti-cancer agents is
laborious, time consuming, and costly with obvious socioeconomic burden. In the present
study, we are proposing new molecular insights on the anti-proliferative and apoptotic
therapeutic effects of nitazoxanide (NTZ) on CRC. NTZ is FDA-approved thiazolide …
